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Lewandowski KE, Shashi V, Berry PM, Kwapil TR. Schizophrenic-like neurocognitive deficits in children and adolescents with 22q11 deletion syndrome. Am J Med Genet B Neuropsychiatr Genet . 2007 Jan 5 ; 144(1):27-36. PubMed Abstract

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Comment by:  Mary Reid
Submitted 25 March 2007 Posted 4 April 2007

Lewandowski and colleagues report that 22q11 deletion syndrome participants exhibited deficits in intelligence, achievement, sustained attention, executive functioning, and verbal working memory compared to controls. It's interesting that eczema and asthma are seen in chromosome 22q11.2 deletion syndrome (Staple et al., 2005). The adenosine A2A receptor is found at 22q11.2 and deficient A2A receptor activity leads to airway inflammation in an asthma model (Nadeem et al., 2007). This would seem to indicate increased A2B receptor activity as a consequence.

A patent issued on October 24, 2006 (, describes an A2B adenosine receptor antagonist for the treatment of type I hypersensitivity disorders, such as asthma, hay fever, and atopic eczema. They also state, "Another adverse biological effect of...  Read more

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