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Annotation

Kamiya A, Tomoda T, Chang J, Takaki M, Zhan C, Morita M, Cascio MB, Elashvili S, Koizumi H, Takanezawa Y, Dickerson F, Yolken R, Arai H, Sawa A. DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum Mol Genet . 2006 Nov 15 ; 15(22):3313-23. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Nick Brandon (Disclosure)
Submitted 21 November 2006 Posted 21 November 2006

The Sawa group have further expanded our knowledge of the complex existing between DISC1 and the molecule Nudel (Ndel1). They had already shown that the two molecules interact through the C-terminus of DISC1 (Ozeki et al., 2003), and in a 2005 Nature Cell Biology paper, they showed the critical role of the DISC1/Ndel1 complex as part of the dynein motor complex at the centrosome and showed that either loss of DISC1 through in utero RNAi, or by disruption of DISC1 function by overexpression of the truncated DISC1 protein, disrupts cortical migration (Kamiya et al., 2005; also see SRF related news story). In this study they have further refined the site of DISC1-Ndel1 interaction on DISC1 to amino acids 802-835 on DISC1. They have also confirmed that two amino acids on Ndel1 are essential for DISC1 binding (LE266/267) as previously published (  Read more


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