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Annotation

Ridler K, Veijola JM, Tanskanen P, Miettunen J, Chitnis X, Suckling J, Murray GK, Haapea M, Jones PB, Isohanni MK, Bullmore ET. Fronto-cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophrenia. Proc Natl Acad Sci U S A . 2006 Oct 17 ; 103(42):15651-6. PubMed Abstract

Comments on Paper and Primary News
Primary News: Brain Imaging Links Motor, Cognitive Deficits in Schizophrenia

Comment by:  Daniel Weinberger, SRF Advisor
Submitted 26 October 2006 Posted 26 October 2006
  I recommend this paper

This paper by Ridler and colleagues is an interesting novel twist on other evidence that developmental milestones, even in traditionally hard wired motor functions, are slightly delayed in samples of individuals who later manifest schizophrenia. There are two important additional results that emerge from their analysis: first, that early developmental motor milestones predict MRI measures of brain volume and executive function during adulthood in normal individuals; and second, that these predictive relationships are not found in their schizophrenia sample.

The link between early motor and adult cognitive development is not surprising, as child development studies have highlighted the predictive implications of precocious motor development for cognitive development. The link to volumetric measures on MRI is intriguing and novel, though as in all MRI volumetry studies, the tissue compartments that contribute to variance in the MRI measures are uncertain. I doubt that MRI volume measures are sensitive assessments of variation in synaptic abundance or other elements related...  Read more


View all comments by Daniel Weinberger

Primary News: Brain Imaging Links Motor, Cognitive Deficits in Schizophrenia

Comment by:  Patricia Estani
Submitted 2 November 2006 Posted 2 November 2006
  I recommend this paper
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