Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Lieberman JA. Comparative effectiveness of antipsychotic drugs. A commentary on: Cost Utility Of The Latest Antipsychotic Drugs In Schizophrenia Study (CUtLASS 1) and Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE). Arch Gen Psychiatry . 2006 Oct 1 ; 63(10):1069-72. PubMed Abstract

Comments on Paper and Primary News
Primary News: Second Test for Second-generation Antipsychotics: Same Old Story?

Comment by:  Patricia Estani
Submitted 19 October 2006 Posted 19 October 2006
  I recommend this paper

Primary News: Second Test for Second-generation Antipsychotics: Same Old Story?

Comment by:  Jan Volavka
Submitted 19 October 2006 Posted 19 October 2006
  I recommend this paper

Based on a study of 227 subjects, Jones and colleagues conclude that “there is no disadvantage …in commencing treatment with FGAs rather than atypical SGAs in people with schizophrena…” (Jones et al., 2006). Jones et al chose to compare two groups (all FGAs v.all SGAs). Although they acknowledge, in general, within-group heterogeneity, they consider the comparison between groups clinically useful. However, this perspective that in fact ignores the heterogeneity is limiting, and, in combination with the results of the study, might encourage clinicians to believe that the effectiveness of all antipsychotics is equal (with the possible exception of clozapine).

A recent report provided evidence of great variability of effectiveness across the spectrum of FGAs and SGAs (Tiihonen et al., 2006). This was an observational prospective cohort study of 2230 adults hospitalized for schizophrenia in Finland. The main outcome...  Read more

View all comments by Jan Volavka

Primary News: Second Test for Second-generation Antipsychotics: Same Old Story?

Comment by:  György Szekeres
Submitted 1 November 2006 Posted 1 November 2006
  I recommend this paper
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright