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Georgieva L, Moskvina V, Peirce T, Norton N, Bray NJ, Jones L, Holmans P, Macgregor S, Zammit S, Wilkinson J, Williams H, Nikolov I, Williams N, Ivanov D, Davis KL, Haroutunian V, Buxbaum JD, Craddock N, Kirov G, Owen MJ, O'Donovan MC. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proc Natl Acad Sci U S A . 2006 Aug 15 ; 103(33):12469-74. PubMed Abstract

Comments on Paper and Primary News
Primary News: OLIG2 Gene Supports Notion of Myelin Abnormalities in Schizophrenia

Comment by:  William Honer
Submitted 4 August 2006 Posted 4 August 2006

This paper demonstrates several important shifts in research strategies for schizophrenia. Many previous studies of candidate genes in the illness have chosen their targets based on concepts of the mechanism of action of antipsychotic drugs, or by virtue of the proximity of a gene to a genetic linkage site defined with anonymous markers. The choice of candidate gene here is based on a wide range of neurobiological evidence, including studies of gene expression and protein levels. As well, the authors do not limit their study to one gene; instead, they expand their investigation to include plausibly interacting gene targets. Analysis of complex disorders will likely need more than simple models, and the approach here is worth noting.

The gap still remains between the DNA-mRNA approaches and protein analysis. Gene expression is one factor determining mRNA levels. However, especially in human brain tissue samples, many other antemortem and postmortem factors contribute to the measured level of mRNA. The meaning of gene expression measures obtained for...  Read more

View all comments by William Honer

Primary News: OLIG2 Gene Supports Notion of Myelin Abnormalities in Schizophrenia

Comment by:  Patricia Estani
Submitted 22 August 2006 Posted 23 August 2006
  I recommend this paper
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