Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Rummel C, Kissling W, Leucht S. Antidepressants for the negative symptoms of schizophrenia. Cochrane Database Syst Rev . 2006 ; 3():CD005581. PubMed Abstract

Comments on Paper and Primary News
Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 30 July 2006 Posted 31 July 2006
  I recommend this paper

Depressed patients with and without schizophrenia have low energy, anhedonia, low motivation. When depression is reduced with antidepressant drugs and time, these negative symptoms improved. What is critical to understand is whether the reduced capacity for volition, motivation, and energy associated with negative symptoms caused by schizophrenia are responsive to antidepressant therapy. Negative symptoms secondary to dysphoric mood are quite different from primary negative symptoms. Rating scales in common use, and providing data in the studies reviewed, do not distinguish between secondary and primary negative symptoms. I believe that we have no credible evidence that primary negative symptoms are therapeutically responsive to antidepressant therapy.

View all comments by William Carpenter

Comment by:  Patricia Estani
Submitted 2 August 2006 Posted 3 August 2006
  I recommend this paper

I would like to express my agreement with the comment of Dr. W. T. Carpenter about the relationship between antidepressants and negative symptoms in schizophrenia. I believe, along with the authors, that at this moment there is little evidence about this relationship. I think that if the outcome of a combined treatment of antipsychotic/antidepressant drugs versus antipsychotic drugs alone is more effective, this effect could be a result from several variables or it could be that the treatment could affect distinctive and separate symptoms that the study did not describe.

As Dr. Carpenter said, the primary negative symptoms are resistant to change, so it is difficult that they were responsive to antidepressants. Thus, the study of the relationship between antidepressant drugs and schizophrenia is an interesting field of study in schizophrenia research.

View all comments by Patricia Estani

Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright