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Jablensky A. Subtyping schizophrenia: implications for genetic research. Mol Psychiatry . 2006 Sep 1 ; 11(9):815-36. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Nick CraddockMichael Owen (SRF Advisor)
Submitted 19 July 2006 Posted 19 July 2006

Assen Jablensky has written a comprehensive and scholarly review of attempts to define valid subtypes of schizophrenia and their implications for genetic research. We are broadly in agreement with the points he makes and the general thrust of his argument, which is that, “The dissection of the syndrome into modular endophenotypes with specific neurocognitive or neurophysiological underpinnings is beginning to be perceived as a promising approach in schizophrenia genetics.” He has, however, misunderstood us if he believes that we (Craddock and Owen, 2005) are advocating replacing the concept of schizophrenia with the pre-Kraepelinian notion of a unitary psychosis. Rather, we believe, like he does, that, “The study of endophenotypes cutting across the conventional diagnostic boundaries may reveal unexpected patterns of associations with symptoms, personality traits, or behavior.”

It is our view that the current diagnostic frameworks are a hindrance to progress in psychiatric research (  Read more

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