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Annotation

Mirnics K, Levitt P, Lewis DA. Critical appraisal of DNA microarrays in psychiatric genomics. Biol Psychiatry . 2006 Jul 15 ; 60(2):163-76. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Stephan Heckers, SRF Advisor
Submitted 29 April 2006 Posted 29 April 2006
  I recommend this paper

Comment by:  Alan Mackay-SimRichard McCurdyFrançois FeronJohn McGrath (SRF Advisor)
Submitted 14 July 2006 Posted 18 July 2006
  I recommend this paper

Mirnics and colleagues have provided a compelling case for the utility of DNA microarrays in psychiatric research. They also draw attention to the pitfalls of using postmortem and non-neural tissues for gene expression studies in psychotic disease (i.e., heterogeneity of diagnosis, treatment, genetic background, postmortem interval, and molecular differences between neural and non-neural tissues). However, the options for obtaining living neural tissues from psychiatric patients and healthy controls are very limited. Mirnics and colleagues noted that tissue derived from biopsy of the olfactory neuroepithelium (Féron et al., 1999) may provide “an excellent and underutilized source of tissue for high-throughput expression profiling experiment.”

We are pleased to report the first application of gene expression microarrays to human olfactory epithelium in schizophrenia and bipolar I disorder (McCurdy et al., 2006)....  Read more


View all comments by Alan Mackay-Sim
View all comments by Richard McCurdy
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