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Annotation

Eaton WW, Byrne M, Ewald H, Mors O, Chen CY, Agerbo E, Mortensen PB. Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. Am J Psychiatry . 2006 Mar 1 ; 163(3):521-8. PubMed Abstract

Comments on Paper and Primary News
Comment by:  John McGrath, SRF Advisor
Submitted 13 March 2006 Posted 13 March 2006

Over the last few decades, a steady stream of studies has suggested links between autoimmune disorders and schizophrenia. However, the findings have been patchy, and often based on under-powered studies. In a new study from Eaton and colleagues at the National Centre for Register-based Research (based in Aarhus, Denmark), it has been convincingly shown that a range of autoimmune disorders positively co-segregate with schizophrenia at both the individual and parental level. This study reconfirms the power of register-based epidemiological research to generate clues that can guide future research.

There are some curious twists to these data. Table 3 shows that Type 1 diabetes appearing before the onset of schizophrenia occurred less frequently compared to control subjects; however, this association was only a trend level (Adjusted Incidence Rate 0.07, 95 percent CI 0.4, 1.0). On the other hand, in the parents of individuals with schizophrenia, Type 1 diabetes was twice as common compared to control parents. The authors also note that rheumatoid arthritis occurred more...  Read more


View all comments by John McGrath

Primary News: Schizophrenia, Autoimmune Diseases Linked in Danish Population

Comment by:  Keith Parker
Submitted 22 March 2006 Posted 22 March 2006
  I recommend this paper

Primary News: Schizophrenia, Autoimmune Diseases Linked in Danish Population

Comment by:  Patricia Estani
Submitted 26 March 2006 Posted 26 March 2006
  I recommend this paper
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