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Annotation

Olson EC, Kim S, Walsh CA. Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. J Neurosci . 2006 Feb 8 ; 26(6):1767-75. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Gabriella D'Arcangelo
Submitted 13 March 2006 Posted 13 March 2006

The recent study by Olson and colleagues (Olson et al., 2006) touches on an important aspect of embryonic brain development that is the poorly understood link between neuronal migration and process maturation during the formation of cortical layers. In the embryonic neocortex principal neurons are generated near the ventricle from neuronal progenitors (radial glia) undergoing their final cell division. The newborn neurons then migrate radially towards the marginal zone and stop near the surface of the cortex. This area is rich in the extracellular protein Reelin, which is well known to be required for cellular layer formation and neurite extension in many areas of the developing brain (D'Arcangelo, 2006). Reelin signaling in cortical neurons is mediated by Dab1, an adaptor protein that is rapidly phosphorylated on tyrosine residues upon exposure to this protein. As neurogenesis proceeds, each cohort of newborn neurons...  Read more


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