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Szabadics J, Varga C, Molnár G, Oláh S, Barzó P, Tamás G. Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits. Science . 2006 Jan 13 ; 311(5758):233-5. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Guillermo Gonzalez-Burgos
Submitted 18 January 2006 Posted 18 January 2006

The paper from Szabadics and colleagues contests two dogmas of GABA neurotransmission: 1) that in the adult brain, the effects of GABA synapses are inhibitory; and 2) that among GABAergic interneuron subclasses, axo-axonic cells (AACs) are probably the most powerfully inhibitory.

Like most GABAergic interneuron subclasses, AACs utilize GABA as their main neurotransmitter and the effects of GABA at AAC synapses are mediated by GABAA receptors, which after binding GABA open a chloride channel. Usually, the opening of GABAA receptor chloride channels produces hyperpolarization and thus inhibition. AACs are unique because they make synapses onto the initial segment of the pyramidal cell axon, close to the site where action potentials are initiated. Because action potential initiation requires depolarization, it was thought that AAC-mediated hyperpolarization was strategically placed: The closer an inhibitory synapse is to the site where action potentials are initiated, the more powerful the inhibition. The claim that AACs were more powerful than other interneurons to inhibit...  Read more

View all comments by Guillermo Gonzalez-Burgos

Primary News: In Sync—Orchestrating Perfect Harmony in Neuronal Networks

Comment by:  Kevin Spencer (Disclosure)
Submitted 9 February 2006 Posted 9 February 2006
  I recommend this paper
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