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Annotation

Newcomer JW. Metabolic risk during antipsychotic treatment. Clin Ther . 2004 Dec ; 26(12):1936-46. PubMed Abstract

Comments on Paper and Primary News
Comment by:  James Manning IV
Submitted 25 November 2005 Posted 25 November 2005
  I recommend this paper

This paper provides good insight into the limitations of trials secondary to confounding design variables.

View all comments by James Manning IV

Comments on Related News
Related News: A Burden on the Heart—Schizophrenia and Coronary Heart Disease

Comment by:  Kiumars Lalezarzadeh
Submitted 27 December 2005 Posted 28 December 2005
  I recommend the Primary Papers

The relation between fatty acid and dopamine needs basic consideration. Two-week-old pups of mother rats fed n-3 polyunsaturated fatty acid-deficient diets (3 weeks before and 2 weeks after birth) showed an increase of D2 (and D1) receptors in the mesolimbic-mesocortical pathways of mothers and many brain areas of the pups (Kuperstein et al., 2005). The depressing effects of increased cholesterol level may be seen in reverse.

The effects of different antipsychotics on the immune system and fungal pathogens need consideration also. Antipsychotics reduce calcineurin protein levels and elevate phosphatase activity of calcineurin in striatum and prefrontal cortex (Rushlow et al., 2005). Calcineurin increases fungal pathogens and its inhibition is related to immune suppression (Cruz et al., 2001). Antipsychotics need further study in relation to...  Read more


View all comments by Kiumars Lalezarzadeh

Related News: A Burden on the Heart—Schizophrenia and Coronary Heart Disease

Comment by:  Robert Peers
Submitted 30 December 2005 Posted 31 December 2005

In what may be a landmark study of lifestyle intervention in schizophrenia, Australian dietitian Sherryn Evans was highly successful in limiting weight gain in newly diagnosed schizophrenia patients treated with olanzapine (Evans et al., 2005). Nutritionally educated patients were only 2 kg heavier after 3 months and 6 months, and were happier; controls were 6 kg and 9.9 kg heavier at the same time points.

The key to nutritional success is close supervision, best provided in community centers accessible to schizophrenia patients. A gym would help. F. M. Baker once ran a program in a poor area of Baltimore, in which the patients were collected daily and brought in, to cook their own (healthy) meals and take part in psychosocial therapy; medication compliance improved, and readmission rates fell dramatically.

The adverse metabolic effects of most newer antipsychotic drugs have stimulated a renaissance of interest in nutritional factors and physical health in schizophrenia that will hopefully...  Read more


View all comments by Robert Peers

Related News: A Burden on the Heart—Schizophrenia and Coronary Heart Disease

Comment by:  Patricia Estani
Submitted 3 January 2006 Posted 4 January 2006
  I recommend the Primary Papers

More studies must be designed to research variables that affect heart disease in schizophrenia. I think that integrating medical services, for example, adding nutritional treatment or dietary services to psychiatric support is essential to prevent the metabolic syndrome commonly observed in schizophrenic patients.

View all comments by Patricia Estani


Related News: A Burden on the Heart—Schizophrenia and Coronary Heart Disease

Comment by:  SuSanne Henriksen
Submitted 10 January 2006 Posted 10 January 2006
  I recommend the Primary Papers

Is there any evidence of an increased incidence of arrhythmias, especially tachycardia, in schizophrenia?

View all comments by SuSanne Henriksen

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