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Annotation

Bowie CR, Harvey PD. Cognition in schizophrenia: impairments, determinants, and functional importance. Psychiatr Clin North Am . 2005 Sep 1 ; 28(3):613-33, 626. PubMed Abstract

Comments on Related News
Related News: Antipsychotics and Cognition: Practice Makes Perfect Confounder

Comment by:  Richard Keefe
Submitted 12 October 2007 Posted 12 October 2007

As stated in the CATIE and CAFÉ neurocognition manuscripts, it is possible that the small improvements in neurocognitive performance following randomization to one of the antipsychotic treatments in these studies are due solely to practice effects or expectation biases. This statement is affirmed by the excellent recent study by Goldberg et al. in which improvements in cognitive performance were almost identical in magnitude to the practice effects found in healthy controls. While these data may be perhaps disappointing to the hope that second-generation medications improve cognition, they may also suggest that cognitive performance is less recalcitrant to change than previously expected.

In the context of a double-blind study design, the degree of cognitive enhancement observed for each treatment group is a function of three major variables: treatment effect, placebo effect, and practice effect. In studies of antipsychotic medications without a placebo control group, practice and placebo effects in schizophrenia cannot be...  Read more


View all comments by Richard Keefe

Related News: Antipsychotics and Cognition: Practice Makes Perfect Confounder

Comment by:  Narsimha Pinninti (Disclosure)
Submitted 15 October 2007 Posted 15 October 2007
  I recommend the Primary Papers

This article questions the prevailing notion that antipsychotic medication (particularly second-generation antipsychotics) improve cognitive functioning in individuals with schizophrenia. As the authors rightly note, practice effects should be taken into account before attributing improvements to drug effects.

View all comments by Narsimha Pinninti


Related News: Antipsychotics and Cognition: Practice Makes Perfect Confounder

Comment by:  Saurabh Gupta
Submitted 15 October 2007 Posted 15 October 2007
  I recommend the Primary Papers

I propose that future studies should use computational cognitive assessment tools like CANTAB or CogTest, which have at least two advantages. These tools have multiple similar test modules, so on each testing during one study, participants get a similar but not the same test to assess the same cognitive function. Besides, computational assessment also reduces chances of subjective bias on the part of investigator.

References:

Levaux MN, Potvin S, Sepehry AA, Sablier J, Mendrek A, Stip E. Computerized assessment of cognition in schizophrenia: promises and pitfalls of CANTAB. Eur Psychiatry. 2007 Mar;22(2):104-15. Review. Abstract

View all comments by Saurabh Gupta


Related News: Antipsychotics and Cognition: Practice Makes Perfect Confounder

Comment by:  Sebastian Therman
Submitted 17 October 2007 Posted 17 October 2007

One remedy would be repeated practice over time before the actual baseline, sufficient to reach asymptotic ability. Computerized testing of reaction time measures, short-term memory span, etc. would all be quite cheap and easy to implement, for example, as a weekly session.

View all comments by Sebastian Therman


Related News: Antipsychotics and Cognition: Practice Makes Perfect Confounder

Comment by:  Andrei Szoke
Submitted 1 November 2007 Posted 5 November 2007
  I recommend the Primary Papers

We recently completed a meta-analysis on "Longitudinal studies of cognition in schizophrenia" (to be published in the British Journal of Psychiatry) based on 53 studies providing data for 31 cognitive variables. When enough data were available (19 variables from eight cognitive tests), we compared the results of schizophrenic participants to those of normal controls.

Given the differences in methods and the fact that most of the studies included in our meta-analysis reported results of patients being past their first episode (FE), it is surprising how close our results and conclusions are compared to those of Goldberg et al. In our analysis we found that, with two exceptions (semantic verbal fluency and Boston naming test, which were stable), participants with schizophrenia improved their performances. The improvement was statistically significant for 19 variables (out of 29). However, controls also showed improvement in most of the variables due to the practice effect. A significant improvement (definite practice effect) was present for 10 variables, an improvement that...  Read more


View all comments by Andrei Szoke

Related News: Antipsychotics and Cognition: Practice Makes Perfect Confounder

Comment by:  Patricia Estani
Submitted 7 November 2007 Posted 8 November 2007
  I recommend the Primary Papers
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