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Annotation

Mitchell RM, Janssen MJ, Karavanova I, Vullhorst D, Furth K, Makusky A, Markey SP, Buonanno A. ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity. Proc Natl Acad Sci U S A . 2013 Nov 26 ; 110(48):19603-8. PubMed Abstract

Comments on Paper and Primary News
Primary News: Research Roundup: PV Interneurons and Neural Circuit (Dys)Function

Comment by:  Takao Hensch
Submitted 15 February 2014 Posted 15 February 2014

Our Conte Center is focused on the transcriptome, connectome, and plasticity of PV cells as the neurodevelopmental basis for mental illness. Their maturational state dictates the degree of plasticity in developmental critical periods, and now we know, from Donato et al., in adult learning. Once plasticity is opened by PV cells' function, it closes when they mature ("high PV" state), including the tightening of the perineuronal nets (PNNs) around them.

In schizophrenia, PV cells may remain in the "low PV" weak PNN state for some time longer than normal, suggesting, interestingly, that developmental plasticity may be prolonged (i.e., neural circuits fail to stabilize when they normally should). PV cell maturation may potentially be controlled by Otx2 secreted from the choroid plexus, which would link enlarged ventricles to impaired PV cells in the brain in schizophrenia (see Spatazza et al., 2013).

References:

Spatazza J, Lee HH, Di Nardo AA, Tibaldi L, Joliot A, Hensch TK, Prochiantz A. Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. Cell Rep. 2013 Jun 27;3(6):1815-23. Abstract

View all comments by Takao Hensch

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