Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Siegel BI, Sengupta EJ, Edelson JR, Lewis DA, Volk DW. Elevated Viral Restriction Factor Levels in Cortical Blood Vessels in Schizophrenia. Biol Psychiatry . 2013 Sep 30 ; PubMed Abstract

Comments on Paper and Primary News
Comment by:  Cynthia Shannon Weickert, SRF Advisor
Submitted 27 December 2013 Posted 27 December 2013

Delving deeper into postmortem brains may be the key to finding new therapies!

I would like to draw attention to this recent outstanding paper by Benjamin Siegel from David Volk’s laboratory, where they found a robust increase in IFITM (interferon induced transcript transmembrane protein) mRNAs in the prefrontal cortex of people with schizophrenia, with ~40 percent of the cases showing levels twice those of controls. Since one function of IFITMs are to protect cells from viral infection, one wonders if this may be the “smoking gun” that points to an increase in viral exposure at some earlier point in the person’s life, a hypothesis for the etiology of schizophrenia that has driven the research of E. Fuller Torrey throughout his career. This indeed may be the case. IFITMs are integral membrane proteins lacking an obvious enzyme domain, and even though the mechanistic role of IFITMs in normal cell function is not entirely clear, they are key players in blocking viral membrane fusion to host cell membranes. However, since IFITMs are expressed constitutively, are found in late...  Read more

View all comments by Cynthia Shannon Weickert
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright