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Ren W, Lui S, Deng W, Li F, Li M, Huang X, Wang Y, Li T, Sweeney JA, Gong Q. Anatomical and Functional Brain Abnormalities in Drug-Naive First-Episode Schizophrenia. Am J Psychiatry . 2013 Jun 4 ; PubMed Abstract

Comments on Paper and Primary News
Comment by:  Lei Wang
Submitted 17 July 2013 Posted 17 July 2013

There are two important contributions that this study brings to the field: 1) it has one of the largest samples of antipsychotic-naïve individuals at the early stages of schizophrenia—while most of the published studies on first-episode schizophrenia/psychosis are of small sample size (Radua et al., 2012), with 100 patients and 100 matched controls, this study provides good statistical power; and 2) it uses multimodal imaging. Although more and more studies have collected multimodal imaging data in an attempt to directly study relationships between brain structure and brain function (Schultz et al., 2012), there exists a dearth of information with regard to the direct relationship between structural changes and changes in resting-state functional connectivity, especially in treatment-naïve patients.

The study also invokes new questions on the neurobiology of treatment-naïve schizophrenia. For example, findings of the study suggest that in drug-naive first-episode schizophrenia...  Read more

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