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Annotation

Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K. Structural and molecular interrogation of intact biological systems. Nature . 2013 Apr 10 ; PubMed Abstract

Comments on Paper and Primary News
Primary News: Brain Anatomy Revealed With CLARITY

Comment by:  Karoly Mirnics, SRF Advisor
Submitted 10 April 2013 Posted 10 April 2013

The Deisseroth lab has done it again! This is an amazing technical advance that can revolutionize the way we do histology and microcircuitry studies. Also, this will be very relevant for human postmortem research, as it will allow better 3-D understanding of the local connectivity. The pictures are very impressive, although I have some potential concerns with the antibody penetration, at least in some cases. In addition, it is noteworthy that this technology will require additional, non-trivial investment in equipment, and it might be (at least initially) best suited for core facilities.

View all comments by Karoly Mirnics


Primary News: Brain Anatomy Revealed With CLARITY

Comment by:  Philip Seeman (Disclosure)
Submitted 11 April 2013 Posted 12 April 2013

Ramón y Cajal is alive and well, but renamed Karl Deisseroth.

View all comments by Philip Seeman
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