Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Annotation

Geerts H, Roberts P, Spiros A. A Quantitative System Pharmacology Computer Model for Cognitive Deficits in Schizophrenia. CPT: Pharmacometrics and Systems Pharmacology . 2013 April 3 ; 2(e36) Abstract

Comments on Paper and Primary News
Comment by:  Bryan Roth, SRF Advisor
Submitted 6 May 2013 Posted 6 May 2013

At the furthest frontier of computational biology are computational approaches to mimic the actions of the human mind and cognition (O’Reilly, 2006). In a recent paper, Hugo Geerts and colleagues "boldly go where no one has gone before" by modeling cognitive deficits in schizophrenia and their amelioration by GABAergic and atypical antipsychotic drugs. Remarkably, predictions from their models accurately recapitulated legacy clinical data. They suggest that such an approach early in the drug discovery pipeline might enhance chances for success by focusing on those compounds predicted to have robust effects on enhancing cognition in schizophrenia. Going forward, it will be interesting for the authors to make similar predictions regarding the large number of drugs proposed for enhancing cognition in schizophrenia (e.g., GlyT1 inhibitors, α7 nicotinic agents, AMPAkines, and so on) (Javitt, 2012; Lieberman et al., 2013).

One of the...  Read more


View all comments by Bryan Roth
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


 
 
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright