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Geerts H, Roberts P, Spiros A. A Quantitative System Pharmacology Computer Model for Cognitive Deficits in Schizophrenia. CPT: Pharmacometrics and Systems Pharmacology . 2013 April 3 ; 2(e36) Abstract

Comments on Paper and Primary News
Comment by:  Bryan Roth, SRF Advisor
Submitted 6 May 2013 Posted 6 May 2013

At the furthest frontier of computational biology are computational approaches to mimic the actions of the human mind and cognition (O’Reilly, 2006). In a recent paper, Hugo Geerts and colleagues "boldly go where no one has gone before" by modeling cognitive deficits in schizophrenia and their amelioration by GABAergic and atypical antipsychotic drugs. Remarkably, predictions from their models accurately recapitulated legacy clinical data. They suggest that such an approach early in the drug discovery pipeline might enhance chances for success by focusing on those compounds predicted to have robust effects on enhancing cognition in schizophrenia. Going forward, it will be interesting for the authors to make similar predictions regarding the large number of drugs proposed for enhancing cognition in schizophrenia (e.g., GlyT1 inhibitors, α7 nicotinic agents, AMPAkines, and so on) (Javitt, 2012; Lieberman et al., 2013).

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