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Asami T, Whitford TJ, Bouix S, Dickey CC, Niznikiewicz M, Shenton ME, Voglmaier MM, McCarley RW. Globally and locally reduced MRI gray matter volumes in neuroleptic-naive men with schizotypal personality disorder: association with negative symptoms. JAMA Psychiatry . 2013 Apr 1 ; 70(4):361-72. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Mark Lenzenweger
Submitted 22 February 2013 Posted 22 February 2013

This is a very good and important new study. As someone who has studied schizotypic psychopathology for nearly three decades, and long argued that schizotypic pathology (including SPD) is a cleaner window on schizophrenia liability, I think this is a very exciting study. It highlights the incredible utility of studying schizotypic pathology as a window on causal mechanisms in schizophrenia. Unclouded by medication, institutionalization, and deterioration effects, these findings in schizotypal personality disorder shed important new light on schizophrenia (see Lenzenweger, 2010, for extended discussion of these ideas).


Lenzenweger, MF. (2010). Schizotypy and schizophrenia: The view from experimental psychopathology. New York: Guilford.

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Comment by:  Erin A. HazlettLarry Siever
Submitted 26 February 2013 Posted 26 February 2013

Frontal-Temporal Gray Matter Volume and Negative Symptoms in Schizophrenia-Spectrum Disorders
The paper by Asami et al. (2013) in the latest issue of JAMA Psychiatry highlights the strengths of studying schizotypal personality disorder (SPD), which is genetically related to and shares common phenomenological, biological, and neurocognitive abnormalities with schizophrenia, but without the overt psychosis. This MRI study has several noteworthy strengths, including a large, never-medicated sample which alleviates medication as a confound. The voxel-based morphometry (VBM) MRI findings indicate reduced gray matter volume in the left superior temporal gyrus and widespread frontal, frontolimbic, and parietal regions in a sample of men with SPD compared with healthy control participants (54 in each group). Consistent with the concept that SPD probably represents a milder form of disease along the schizophrenia continuum, reduced superior temporal gyrus volume has consistently been reported in SPD and schizophrenia (Dickey et...  Read more

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