Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, Reynolds AP, Sandstrom R, Qu H, Brody J, Shafer A, Neri F, Lee K, Kutyavin T, Stehling-Sun S, Johnson AK, Canfield TK, Giste E, Diegel M, Bates D, Hansen RS, Neph S, Sabo PJ, Heimfeld S, Raubitschek A, Ziegler S, Cotsapas C, Sotoodehnia N, Glass I, Sunyaev SR, Kaul R, Stamatoyannopoulos JA. Systematic localization of common disease-associated variation in regulatory DNA. Science . 2012 Sep 7 ; 337(6099):1190-5. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Patrick Sullivan, SRF Advisor
Submitted 12 September 2012 Posted 12 September 2012

This Science paper has bearing on the genomic basis of complex traits, including schizophrenia, autism, and bipolar disorder(Maurano et al., 2012). A related paper in Nature will be of great interest to genomicists (ENCODE Project Consortium, 2012)

A major quandary in human genetics is how to understand the findings of genome-wide association studies for complex traits. This body of knowledge is now pretty huge: the NHGRI GWAS catalog (downloaded 22 June 2012, filtered for p < 1x10-8 and keeping the smallest p value if there were multiple SNP-trait pairs) contains genome-wide significant results for 2,441 SNPs, 385 traits, and 2,968 SNP-trait pairs from 672 papers. These associations are common (median minor allele frequency 0.29) and of subtle effect (median genotypic relative risk 1.19).

The diseases with the greatest number of associations are: Crohn's disease (94), ulcerative colitis (56), type 2 diabetes mellitus (56), type 1 diabetes mellitus (47), coronary artery...  Read more

View all comments by Patrick Sullivan
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright