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Annotation

Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, Thorleifsson G, Gudbjartsson DF, Helgason A, Magnusson OT, Thorsteinsdottir U, Stefansson K. Rate of de novo mutations and the importance of father's age to disease risk. Nature . 2012 Aug 23 ; 488(7412):471-5. PubMed Abstract

Comments on Paper and Primary News
Primary News: New Mutations Mount as Fathers Age

Comment by:  Dolores Malaspina
Submitted 27 August 2012 Posted 27 August 2012

The new report by Kong et al. (2012) demonstrates that...  Read more


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Primary News: New Mutations Mount as Fathers Age

Comment by:  Patrick Sullivan, SRF Advisor
Submitted 27 August 2012 Posted 27 August 2012

Kong et al. sequenced 78 pedigree clusters (mostly...  Read more


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Primary News: New Mutations Mount as Fathers Age

Comment by:  John McGrath, SRF Advisor
Submitted 28 August 2012 Posted 28 August 2012
  I recommend this paper

In 2001, Dolores Malaspina alerted the research community...  Read more


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Primary News: New Mutations Mount as Fathers Age

Comment by:  Georg Winterer (Disclosure)
Submitted 28 August 2012 Posted 28 August 2012
  I recommend this paper

Just a few thoughts:

One question is whether it is...  Read more


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Primary News: New Mutations Mount as Fathers Age

Comment by:  Michael O'Donovan, SRF AdvisorGeorge Kirov
Submitted 31 August 2012 Posted 31 August 2012

In a genomic sequencing study of 78 parent-proband trios...  Read more


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View all comments by George Kirov

Primary News: New Mutations Mount as Fathers Age

Comment by:  Bernard Crespi
Submitted 3 September 2012 Posted 5 September 2012
  I recommend this paper

Kong et al. (2012) is an outstanding paper that provides...  Read more


View all comments by Bernard Crespi
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