Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

[No authors listed]. Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biol Psychiatry . 2012 Oct 15 ; 72(8):620-8. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Patrick Sullivan, SRF Advisor
Submitted 30 August 2012 Posted 30 August 2012

This is an important new study from the Irish Schizophrenia Genomics Consortium and the second wave of the Wellcome Trust Case-Control Consortium (WTCCC).

The study is notable, as it found genomewide significance for an association of schizophrenia with genetic variation in the major histocompatibility locus (MHC). Given concerns about stratification effects at this locus, it is notable that this association was significant in a sample from a single country with relatively homogeneous ancestry. Prior studies had combined data from multiple different countries, and these results provide an important consistency check.

In addition, the authors provide important suggestive evidence for a specific variant in a class 1 MHC locus (HLA-C gene, the "01:02" variant, p = 3e-4).

The use of 1000 Genomes Project data for imputation is notable for the improved signal pattern it appeared to afford.

View all comments by Patrick Sullivan

Comment by:  Monojit Debnath
Submitted 29 August 2012 Posted 31 August 2012
  I recommend this paper

The newly reported HLA-C*01:02 as a risk factor of schizophrenia by Strange et al., 2012, in this GWAS (Irish Schizophrenia Genomics Consortium & the Wellcome Trust Case Control Consortium) is a significant contribution and has further strengthened MHC’s role in schizophrenia. Although multiple GWAS in various populations have implicated MHC as a major and best replicated risk loci of schizophrenia (as reviewed in Debnath et al., 2012), the findings remained inconclusive.

Strange et al. (2012), in this GWAS on 1,606 schizophrenia patients and 1,794 controls, found association of three SNPs (rs204999, rs2523722, and rs7746922) within the MHC region with schizophrenia, of which the most significant association was with rs204999. They also replicated this study by considering some selected SNPs in a large, independent set of 13,195 schizophrenia patients and 31,021 controls. In the combined samples (this GWAS and replication data), rs2523722 appeared as the most significantly associated MHC variant. Intriguingly, these findings...  Read more

View all comments by Monojit Debnath
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright