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Owald D, Khorramshahi O, Gupta VK, Banovic D, Depner H, Fouquet W, Wichmann C, Mertel S, Eimer S, Reynolds E, Holt M, Aberle H, Sigrist SJ. Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. Nat Neurosci . 2012 Aug 5 ; PubMed Abstract

Comments on Paper and Primary News
Primary News: Neurexin-Neuroligin Regulate Synapse Form and Function

Comment by:  Christian Schaaf
Submitted 14 August 2012 Posted 14 August 2012

Neurexins and neuroligins are some of the best-characterized cell-adhesion molecules. They are trans-synaptic cell-adhesion molecules that mediate essential signaling between pre- and postsynaptic specializations, signaling that performs a central role in the brain’s ability to process information, and that is a key target in the pathogenesis of cognitive diseases (Südhof, 2008). And indeed, all human neurexin genes (NRXN1, NRXN2, NRXN3) and all (NLGN1, NGLN3, NLGN4X, NLGN4Y) but one human neuroligin gene (NLGN2) have been associated with autism. In addition, NRXN1 has also been associated with schizophrenia with high confidence (Kirov et al., 2009). Recent studies about neurexins and neuroligins are now making some inroads in two directions: 1) genotype-phenotype correlations, and 2) the basic science of how neurexins and neuroligins participate in the assembly of pre- and postsynaptic membranes, and how they mediate signaling between the two.

1. Schaaf et al. (  Read more

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