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Roussos P, Katsel P, Davis KL, Siever LJ, Haroutunian V. A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples. Arch Gen Psychiatry . 2012 Aug 6 ; :1-11. PubMed Abstract

Comments on Paper and Primary News
Primary News: A Bird’s Eye View of the Schizophrenia Transcriptome

Comment by:  Karoly Mirnics, SRF Advisor
Submitted 28 August 2012 Posted 28 August 2012

This is perhaps the best and most comprehensive transcriptome dataset of schizophrenia generated to date. It has multiple strengths, including the use of four different cortical regions, the correlation of genetics with transcriptomics, and the use of strong bioinformatics including WGCNA analysis. The findings are quite revealing. The results suggest that there is a strong, common signature across brain areas BA21, BA32, and BA38 that encompasses genes related to transcription/translation, signal transduction, the cell cycle, cell adhesion, the immune response, apoptosis, and the cytoskeleton.

Perhaps surprisingly, the expression signature was far less prominent in prefrontal cortical area BA 46, which is one of the most affected regions in schizophrenia. However, it was also clear that each brain region had a unique, region-specific schizophrenia signature. In addition, this study reproduced and validated a number of previously reported findings related to oligodendrocyte and mitochondrial transcript deficits. Nevertheless, the results of the current study disagree with...  Read more

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