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Schmidt EF, Warner-Schmidt JL, Otopalik BG, Pickett SB, Greengard P, Heintz N. Identification of the Cortical Neurons that Mediate Antidepressant Responses. Cell . 2012 May 25 ; 149(5):1152-63. PubMed Abstract

Comments on Paper and Primary News
Primary News: Cortical Neurons Underlying Antidepressant Effects Identified

Comment by:  Lei ZhangDavid M. BenedekCarol S. FullertonRobert J. Ursano
Submitted 29 May 2012 Posted 29 May 2012

P11 (S100A10) in cortical neurons' response to antidepressants: A new story for p11
The potential role of p11 (S100A10) in the pathogenesis of psychiatric illness is gaining increasing interest in the neuroscience community. Recent studies suggest that p11 may be important in a number of disorders including posttraumatic disorder (PTSD) and depression (Su et al., 2009; Zhang et al., 2011; Zhang et al., 2008; Svenningsson and Greengard, 2007; Verma et al., 2007; Warner-Schmidt et al., 2009). P11 has been considered as a potential biomarker or therapeutic target for the treatment of depression and PTSD (Su et al., 2009; Zhang et al., 2011; Svenningsson and...  Read more

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