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Kerin T, Ramanathan A, Rivas K, Grepo N, Coetzee GA, Campbell DB. A noncoding RNA antisense to moesin at 5p14.1 in autism. Sci Transl Med . 2012 Apr 4 ; 4(128):128ra40. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Karoly Mirnics, SRF Advisor
Submitted 12 April 2012 Posted 12 April 2012

Well done! In addition to DNA sequence diversity, methylation, transcriptional and translational regulation of gene expression, miRNA silencing, alternative splicing, phosphorylation, and trafficking, now we have to think about gene function regulation by antisense RNA pseudogenes, which are very common in the human genome. The Campbell group builds a compelling case that this is a powerful, active, and disease-associated mechanism in autism (and possibly other brain disorders), showing that the moesin pseudogene 1 (MSNP1AS) transcript acts as an endogenous silencer of the moesin gene (MSN). The study builds on GWAS data (SNP rs4307059, associated with autism spectrum diagnosis), identifies a transcript of interest (MSNP1AS), shows disease-context (individuals who carry the ASD-associated rs4307059 T allele showed increased expression of MSNP1AS), report high overexpression in postmortem cerebral cortex of individuals with ASD, and proves functionality (MSNP1AS noncoding RNA binds to MSN, and could regulate levels of moesin protein in human cell lines).

The implications of...  Read more

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