Lee SH, Decandia TR, Ripke S, Yang J, , , , Sullivan PF, Goddard ME, Keller MC, Visscher PM, Wray NR.
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.
Nat Genet
.
2012 Mar
;
44(3):247-50.
PubMed
Abstract
This is an interesting analytic paper which tests the hypothesis that common genomic variants are responsible for a substantial proportion of the variance in genomewide association studies of schizophrenia.
As large-scale efforts to fully sequence genomes of individuals with schizophrenia are underway at many centers, it will be interesting to revisit this hypothesis.