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Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C. MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proc Natl Acad Sci U S A . 2012 Feb 21 ; 109(8):3125-30. PubMed Abstract

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Comment by:  Vladimir Vladimirov
Submitted 4 April 2012 Posted 4 April 2012

In Miller’s study, published on February 21 in the Proceedings of the National Academy of Sciences, the authors, using a microarray-based approach, have evaluated the genomewide expression of 854 miRNAs in prefrontal cortex from subjects afflicted with schizophrenia and bipolar disorder. At an FDR of 5 percent, only two miRNAs, hsa-miR-132 and -132*, were significantly underexpressed in the schizophrenic group, and were subsequently verified in a second postmortem brain cohort. Over 200 gene targets for miR-132 were predicted and, based on the Ingenuity Pathway analysis, some of the gene targets were in pathways associated with synaptic functions, neuronal CREB signaling, and DNA methylation. As pointed out by the authors, these pathways have been involved in the glutamatergic and dopaminergic hypotheses of schizophrenia, and the fact that miR-132 could exercise control over gene targets belonging to these pathways lends additional support for the potential involvement of miR-132 in schizophrenia. Using mouse models, the authors have also provided evidence for a...  Read more

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