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Annotation

Wang CC, Held RG, Chang SC, Yang L, Delpire E, Ghosh A, Hall BJ. A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function. Neuron . 2011 Dec 8 ; 72(5):789-805. PubMed Abstract

Comments on Paper and Primary News
Primary News: Probing the Role of NMDA Receptor NR2B in Development and Schizophrenia

Comment by:  Stefan KolataKazu Nakazawa
Submitted 21 February 2012 Posted 21 February 2012

The original NMDA receptor (NMDAR) hypofunction theory of schizophrenia was predicated on the discovery that, in adulthood, NMDAR antagonists mimicked disease symptomatology and exacerbated symptoms in schizophrenic patients (Javitt and Zukin, 1991). Recent advances have since shown that, in addition to this effect in adulthood, there may be a postnatal developmental sensitive period necessary for NMDAR hypofunction to later manifest as schizophrenia phenotypes. For instance, in mice, schizophrenia-like phenotypes were observed when NR1 (GluN1) was ablated selectively in corticolimbic interneurons after postnatal day 7, but not when the knockout occurred after adolescence (Belforte et al., 2010). Similarly, transient antagonism of NMDA during development later resulted in schizophrenia-like phenotypes in adult rats (Stefani and Moghaddam, 2005; Baier et al., 2009). In the present work by Wang...  Read more


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