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Raznahan A, Lerch JP, Lee N, Greenstein D, Wallace GL, Stockman M, Clasen L, Shaw PW, Giedd JN. Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling. Neuron . 2011 Dec 8 ; 72(5):873-84. PubMed Abstract

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Comment by:  Tonya White
Submitted 20 December 2011 Posted 20 December 2011

Maturational Coupling and Neurodevelopmental Trajectories
Raznahan and colleagues (Raznahan et al., 2011) present an interesting article that evaluates maturation coupling of brain regions in a large, longitudinal cohort of typically developing children and adolescents. The authors utilized a correlation-based approach to map distinct brain regions that most closely follow similar growth trajectories, which they coin "maturational coupling." Their results replicate prior findings from their group (Shaw et al., 2008), but are extended to show that the structural brain regions involving the default-mode network also demonstrate similar maturational coupling, thus forming a structure/function relationship within this network. "Regions that wire together, grow together, and fire together" … perhaps?

One weakness of the study, as noted also by the authors, is that the growth trajectories are modeled using linear parameters, when it is well known that neurodevelopmental...  Read more

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