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Annotation

Shao L, Shuai Y, Wang J, Feng S, Lu B, Li Z, Zhao Y, Wang L, Zhong Y. Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Proc Natl Acad Sci U S A . 2011 Nov 15 ; 108(46):18831-6. PubMed Abstract

Comments on Paper and Primary News
Primary News: Parsing Dysbindin’s Roles in the Brain

Comment by:  Antonieta Lavin
Submitted 9 November 2011 Posted 10 November 2011
  I recommend this paper

The findings by Shao and collaborators are very exciting, and since their preparation allows for very sophisticated genetic manipulations, the possibility of isolating and reversing the effects of lack of dysbindin in neurons and glia provide important insights into the function of this extremely interesting protein. One result of the study that is relevant for future therapeutic endeavors is the finding that adding glycine to the diet of mutant flies improved memory. We have shown (Glen et al., 2009) that adding glycine to the perfusion buffer of a hippocampal slice preparation from dysbindin-null mice (C57) restored the decreased LTP levels in the null mice without affecting LTP in the WT genotype. Moreover, Shao and colleagues' finding stresses the important role of dysbindin in regulating NMDA receptors. We have already demonstrated that NMDA currents are decreased in dysbindin-null mice, as is expression of the obligatory NMDA receptor subunit (NR1). Furthermore, the degree of NR1 expression directly correlates with performance on a spatial working memory task, providing...  Read more


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