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Bradshaw NJ, Soares DC, Carlyle BC, Ogawa F, Davidson-Smith H, Christie S, Mackie S, Thomson PA, Porteous DJ, Millar JK. PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci . 2011 Jun 15 ; 31(24):9043-54. PubMed Abstract

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Comment by:  Atsushi Kamiya
Submitted 12 August 2011 Posted 12 August 2011

This paper from Millar and Porteous’s group (Bradshaw et al., 2011) proposes a mechanistic link between PDE4 and the NDE1/NDEL1/LIS1 protein complex via a DISC1 pathway. The data suggested that the PKA phosphorylation of NDE1 modulates the protein binding among NDE1, NDEL1, and LIS1, which is regulated by DISC1-PDE4 interaction. Importantly, the authors specified threonine 131 (T131) of NDE1 as a PKA phosphorylation site and produced a phospho-NDE1-T131 antibody. Thus, the question arising is, What is the effect of the phosphorylation of NDE1 at T131 for brain development? Of interest, the authors observed the accumulation of phosphorylated NDE1 at T131 in the centrosome, spindle pole, and intercellular bridge in mitotic cells, as well as in the post-synaptic density in primary hippocampal neurons. The role for the phosphorylation of NDE1 for neuronal processes, such as cell proliferation, differentiation, and synaptic function, is expected to be studied in vivo.

Another question is whether the phosphorylation of NDE1 at T131...  Read more

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