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Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M. Induction of human neuronal cells by defined transcription factors. Nature . 2011 Aug 11 ; 476(7359):220-3. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Kristen BrennandFred Gage
Submitted 3 June 2011 Posted 3 June 2011

In part due to the lack of patient material for study, the molecular mechanisms responsible for many central nervous system (CNS) diseases are not well understood. Fibroblasts from patients and controls can be directly reprogrammed into human induced pluripotent stem cells (hiPSC) and subsequently differentiated into disorder-specific neurons. hiPSCs represent a new strategy for studying disease; a number of recent publications have demonstrated that CNS diseases ranging from type I spinal muscular atrophy (Ebert et al., 2009), familial dystonia (Lee et al., 2009), Parkinson’s disease (PD) (Park et al., 2008; Soldner et al., 2009), amyotrophic lateral sclerosis (ALS) (Dimos et al., 2008), Rett's syndrome (Hotta et al., 2009; Marchetto et al., 2010), and...  Read more

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