Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Sun C, Cheng MC, Qin R, Liao DL, Chen TT, Koong FJ, Chen G, Chen CH. Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia. Hum Mol Genet . 2011 Aug 1 ; 20(15):3042-51. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Anna Need
Submitted 25 May 2011 Posted 25 May 2011

Sun et al. sequenced a cohort of 584 schizophrenia patients and 549 controls to look for rare variants in the NLGN2 gene. They found several missense variants, but no significant excess in cases (8/584 vs. 2/549, p = 0.07). Polyphen predicted one (a case-only variant) to be probably damaging, and another to be possibly damaging, and the rest to be benign. Their own extensive functional work showed the “possibly damaging” one to have no obvious effect on function; rather, it was a loss-of-function mutation. The patient had no family history of mental illness, yet the mutation was shared by the one relative from whom they could obtain DNA—an unaffected brother—suggesting that it was inherited from one of the unaffected parents.

Overall, although the variant certainly seems to be functional, there isn’t really any good evidence that it is involved in schizophrenia in this patient. The gene is a good candidate, but there was no evidence for an excess of mutations in the schizophrenia patients versus the controls. The family history, the presence in the unaffected...  Read more

View all comments by Anna Need
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright