Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Annotation

Tomita K, Kubo K, Ishii K, Nakajima K. Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development. Hum Mol Genet . 2011 Jul 15 ; 20(14):2834-45. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Albert H. C. Wong
Submitted 1 June 2011 Posted 1 June 2011

This paper reports that reduced expression of DISC1 during late embryonic development (E15) impairs the migration of hippocampal pyramidal neurons into CA1, and disrupts the alignment and position of these neurons. Using in utero electroporation of RNAi against endogenous DISC1, the authors were able to disrupt hippocampal development and rescue the anatomical defects by expressing an RNAi-resistant DISC1. This paper provides further information about the important role of DISC1 in neuron migration during brain development, and is consistent with a number of similar studies of the cortex. Neuron migration problems have long been hypothesized to underlie the histopathological abnormalities seen in postmortem brain from patients with schizophrenia. This study and other recent work make it increasingly plausible to speculate that schizophrenia-associated variants in the DISC1 gene might affect the development of the cortex and hippocampus in patients with the disease.

It would be interesting to know the behavioral effects of DISC1 RNAi knockdown in the hippocampus, and to...  Read more


View all comments by Albert H. C. Wong
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Affiliation  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Password  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
 
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:


 
 
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright