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Dias EC, Butler PD, Hoptman MJ, Javitt DC. Early Sensory Contributions to Contextual Encoding Deficits in Schizophrenia. Arch Gen Psychiatry . 2011 Mar 7 ; PubMed Abstract

Comments on Paper and Primary News
Primary News: Poor Working Memory Starts Early in Processing Pipeline

Comment by:  Steven Silverstein
Submitted 19 June 2011 Posted 19 June 2011
  I recommend this paper

This new paper by Dias et al. is important in at least two respects. First, it is further evidence of visual processing impairment in schizophrenia. Second, and perhaps more importantly, as noted by the authors, the findings provide more evidence that schizophrenia is not primarily a disorder of cognitive control or prefrontal cortex function. That is, while schizophrenia does involve those impairments, it appears likely that they can be viewed as 1) being affected by inadequate representations emerging from more basic aspects of processing such as perception; and 2) being due to a primary disorder of neural network formation and maintenance—a widespread failure that affects all aspects of cognitive functioning. These points are discussed in detail in a forthcoming theme section of Schizophrenia Bulletin on Vision Science and Schizophrenia Research.

As noted by Javitt in the article summary, the findings by Dias et al. suggest “that not only are the frontal activation deficits in schizophrenia due to sensory deficits, but, in fact, the behavioral deficits are really...  Read more

View all comments by Steven Silverstein

Primary News: Poor Working Memory Starts Early in Processing Pipeline

Comment by:  Michael F. Green, SRF Advisor
Submitted 30 June 2011 Posted 30 June 2011

The paper by Dias et al. makes an important contribution to our understanding of perceptual processes in schizophrenia. Steve Silverstein has already provided a thoughtful and detailed comment on it. I have just three points to add:

First, the authors provide an excellent demonstration of the explanatory value of bottom-up perceptual processing for vigilance and working memory tasks, such as the AX version of the continuous performance task. However, the implications extend beyond such tasks. There is increasing support for the importance of early perceptual processes (both auditory and visual) for social cognition, including prosody detection and social perception (Leitman et al., 2005; Wynn et al., 2010). In addition, early visual processing has been part of outcome models that reach to community functioning (Rassovsky et al., 2011; Butler et al., 2005). Therefore, the value of...  Read more

View all comments by Michael F. Green
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