Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Li B, Piriz J, Mirrione M, Chung C, Proulx CD, Schulz D, Henn F, Malinow R. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature . 2011 Feb 24 ; 470(7335):535-9. PubMed Abstract

Comments on Paper and Primary News
Primary News: Synaptic Hyperactivity in the Lateral Habenula Linked to Depression

Comment by:  Alexander SartoriusAndreas Meyer-Lindenberg
Submitted 16 March 2011 Posted 16 March 2011

Deep midline structures of our brain seem to contribute considerably to risk for psychiatric illnesses (Northoff et al., 2010). The lateral habenula could be a bottleneck of information flow between midline and cortical structures. Since efferents of the lateral habenula influence all three monoaminergic systems, a contribution to depression risk has been hypothesized (Sartorius and Henn, 2007). One efferent pathway projects via the rostromedial tegmental nucleus to the ventral tegmental area (VTA). Dopaminergic neurons then project to the ventral striatum, reflecting a major part of the brain’s reward system.

The paper by Li et al. further characterizes this pathway by means of electrophysiology and narrows the gap to human depression. It is the first time that not only overactivation of the whole structure but excessive firing rates of specific neurons within the structure were observed in an animal model of depression. Furthermore, dendritic spine density of VTA-projecting...  Read more

View all comments by Alexander Sartorius
View all comments by Andreas Meyer-Lindenberg
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright