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Annotation

Pinault D. Dysfunctional thalamus-related networks in schizophrenia. Schizophr Bull . 2011 Mar ; 37(2):238-43. PubMed Abstract

Comments on Related News
Related News: A New Case for Thalamic Dysfunction in Schizophrenia

Comment by:  Didier Pinault
Submitted 28 March 2012 Posted 1 April 2012
  I recommend the Primary Papers

Schizophrenia and Thalamus Dysfunction
The pathophysiology of schizophrenia still conceals many secrets (Meyer-Lindenberg, 2010; Insel, 2010), which is the reason why the neurobiology of schizophrenia is the relentless object of experimental and clinical investigations. These point out that schizophrenia is a complex, multifunctional disorder involving dysfunctional networks.

Guller and colleagues recently published, in the Archives of General Psychiatry (published online March 5, 2012), clinical data in favor of the hypothesis of thalamic dysfunction in schizophrenia. The authors’ objective was to test the hypothesis that the thalamus of patients with schizophrenia responds abnormally to cortical activation. The authors used fMRI to record in healthy subjects and patients with schizophrenia the vascular response in their cerebral cortex (medial superior frontal cortex [mSFC] and insula) and thalamus following a single...  Read more


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