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Lafourcade M, Larrieu T, Mato S, Duffaud A, Sepers M, Matias I, De Smedt-Peyrusse V, Labrousse VF, Bretillon L, Matute C, Rodríguez-Puertas R, Layé S, Manzoni OJ. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci . 2011 Mar ; 14(3):345-50. PubMed Abstract

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Comment by:  Leonora LongCynthia Shannon Weickert (SRF Advisor)
Submitted 28 July 2011 Posted 28 July 2011

Omega-3 Fatty Acid Levels and Mental Health: Focus on Endocannabinoids and Schizophrenia
Deficiency in dietary omega-3 fatty acid intake appears to favor higher levels of omega-6 acids, which has implications for metabolites downstream of these two fatty acid precursors, including endogenous cannabinoids. While the excellent recent study in Nature Neuroscience (Lafourcade et al., 2011) did not find that increased omega-6 levels corresponded to altered levels of the two major endocannabinoids, 2-AG and anandamide, it did show that it led to a functional reduction of cannabinoid CB1R efficacy and decoupling of CB1R from its inhibitory G protein signaling. This is extremely interesting, given the evidence for changes in endocannabinoid function in schizophrenia (De Marchi et al., 2003; Eggan et al., 2008; Eggan et al., 2010; Dalton et al.,...  Read more

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