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Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci . 2011 Jan 5 ; 31(1):15-25. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Bo Li
Submitted 7 April 2011 Posted 7 April 2011

As both NRG1 and ErbB4 have been linked to schizophrenia, the biological function of this signaling pathway in the CNS has been an area of intensive study. Recent studies indicate that NRG1-ErbB4 signaling may play an important role in the development of glutamatergic synapses (e.g., Fazzari et al., 2010). Since ErbB4 is highly expressed in a subset of GABAergic interneurons in the cortex and hippocampus, including parvalbumin (PV) positive interneurons, it is important to understand the role of NRG1-ErbB4 in synapse development specifically in GABAergic interneurons.

The recent study by Ting et al., a group led by Dr. Lin Mei in the Medical College of Georgia, provides new evidence that the NRG1-ErbB4 signaling pathway plays an important role in regulating the development and function of excitatory synapses in cortical and hippocampal GABAergic interneurons. By applying NRG1 to cultured neurons, they found that NRG1 increases the frequency and amplitude of miniature EPSCs, which is accompanied by an increase in the number...  Read more

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Primary News: Neuregulin and ErbB4: Synaptic Jacks of All Trades

Comment by:  Michael CahillPeter Penzes
Submitted 29 April 2011 Posted 29 April 2011
  I recommend this paper

The recent study by Pitcher et al. provides a novel mechanism linking NRG1/ErbB4 activity to the suppression of NMDAR activity in a manner requiring Src kinase inhibition. The study uses biochemical manipulation of Src activation, as well as studies on cells lacking Src, to examine the role for Src kinase on the effects of NRG1 on NMDAR responses in pyramidal neurons. Overall, the study provides convincing evidence indicating that Src inhibition by NRG1 is an important contributor to the effects of NRG1 on NMDAR pyramidal neuronal hypofunction. The effect of NRG1 and ErbB4 on Src family kinase activation remains complex. Previous studies have found that NRG1 can activate Src, and that inhibition of Src family kinases can block some of the effects of NRG1 on cells, including cellular migration and proliferation (Eckert et al., 2009; Grossmann et al., 2009). Moreover, ErbB4 activity is able to activate fyn when overexpressed in heterologous cells, and NRG1 treatment activates fyn in...  Read more

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