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Annotation

Rodriguez AL, Grier MD, Jones CK, Herman EJ, Kane AS, Smith RL, Williams R, Zhou Y, Marlo JE, Days EL, Blatt TN, Jadhav S, Menon UN, Vinson PN, Rook JM, Stauffer SR, Niswender CM, Lindsley CW, Weaver CD, Conn PJ. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol . 2010 Dec ; 78(6):1105-23. PubMed Abstract

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Comment by:  Anand Gururajan
Submitted 18 October 2010 Posted 18 October 2010

The use of PCP/amphetamine-induced hyperlocomotion in rats is probably insufficient to conclusively state whether a novel compound has antipsychotic potential or not. A more comprehensive battery of tests, including, perhaps, PPI and social interaction, would provide a clearer picture.

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