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Annotation

Oler JA, Fox AS, Shelton SE, Rogers J, Dyer TD, Davidson RJ, Shelledy W, Oakes TR, Blangero J, Kalin NH. Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. Nature . 2010 Aug 12 ; 466(7308):864-8. PubMed Abstract

Comments on Paper and Primary News
Primary News: How Nature and Nurture Form an Anxious Temperament

Comment by:  Jenni BlackfordStephan Heckers (SRF Advisor)
Submitted 21 September 2010 Posted 21 September 2010
  I recommend this paper

Studies of the biological bases of temperament can provide critical insights into why certain individuals are at increased risk for psychiatric disease. The study by Oler and colleagues makes an important contribution to the field by assessing the heritability of temperament-related brain activity in a large colony of pre-adolescent rhesus monkeys. The authors used a standard human intruder paradigm to elicit the phenotypic behavior and concomitant brain activity associated with anxious temperament. Temperament-related brain activity was first identified by correlating anxious temperament with glucose metabolism, the measure of brain activity. Next, heritability estimates were calculated for each voxel in these brain regions. Activity in both the amygdala and hippocampus were correlated with anxious temperament. The amygdala finding confirms previous studies of increased amygdalar activity in both monkeys and humans with an anxious temperament; however, amygdalar activity was not heritable. Instead, the temperament-associated activation in the anterior hippocampus was...  Read more


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