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Matigian N, Abrahamsen G, Sutharsan R, Cook AL, Vitale AM, Nouwens A, Bellette B, An J, Anderson M, Beckhouse AG, Bennebroek M, Cecil R, Chalk AM, Cochrane J, Fan Y, Féron F, McCurdy R, McGrath JJ, Murrell W, Perry C, Raju J, Ravishankar S, Silburn PA, Sutherland GT, Mahler S, Mellick GD, Wood SA, Sue CM, Wells CA, Mackay-Sim A. Disease-specific, neurosphere-derived cells as models for brain disorders. Dis Model Mech . 2010 Nov-Dec ; 3(11-12):785-98. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Shin-ichi KanoAkira Sawa (SRF Advisor)
Submitted 16 August 2010 Posted 19 August 2010

The new paper from Alan Mackay-Sim’s group on molecular profiling with human olfactory neurosphere-derived cell lines (ONS cells) obtained from the olfactory epithelium (OE) of healthy controls and patients with either schizophrenia or Parkinson’s disease is superb. The research group in Australia, including Mackay-Sim and John McGrath, is one of the pioneers that have been studying the olfactory epithelium in schizophrenia research. In this paper, they have, in particular, identified dysregulation of the molecular expression in neurodevelopmental pathways in schizophrenia.

Although postmortem brains have been valuable for exploring disease-specific changes, there are two major limitations. First, even if some changes exist during early neurodevelopment in patients with schizophrenia, such changes may have disappeared, been compensated for, or modified in aged brains. Second, there are many confounding factors that disturb straightforward interpretations of the data from postmortem brains, including effects of long-term use of medications, drug abuse, smoking,...  Read more

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