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Annotation

Rimol LM, Hartberg CB, Nesvåg R, Fennema-Notestine C, Hagler DJ, Pung CJ, Jennings RG, Haukvik UK, Lange E, Nakstad PH, Melle I, Andreassen OA, Dale AM, Agartz I. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry . 2010 Jul 1 ; 68(1):41-50. PubMed Abstract

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Comment by:  Matthew J. Smith
Submitted 31 August 2010 Posted 31 August 2010

Schizophrenia and psychotic mood disorders such as bipolar disorder share a common genetic susceptibility (Lichtenstein et al., 2009) and several clinical characteristics (Glahn et al., 2006; Barch, 2009) that make the confirmation of diagnosis rather difficult. In order to identify whether schizophrenia and bipolar disorder share a similar pathophysiology, research must compare their neurobiology. Rimol and colleagues (2010) recently published an elegant study comparing cortical thickness and subcortical volumes among individuals with schizophrenia and bipolar disorder. Using a sound methodology, they did not conclude that cortical thinning in any region was specific to schizophrenia. This was somewhat surprising, given that the schizophrenia group had significant thinning when compared to controls, while the bipolar group did not differ from controls. However, the bipolar group did not differ from the schizophrenia group, either. The...  Read more


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