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Annotation

Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR. Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell . 2010 May 28 ; 141(5):775-85. PubMed Abstract

Comments on Paper and Primary News
Primary News: Bone Marrow and Aspirin: New Ingredients in Biological Psychiatry

Comment by:  Christopher Pittenger
Submitted 18 June 2010 Posted 22 June 2010
  I recommend this paper

The recent study from the Capecchi laboratory, in which the excessive grooming phenotype observed in HoxB8 knockout mice (Greer and Capecchi, 2002) was found to be mediated by the absence of HoxB8 in hematopoietically derived cells rather than in neurons, represents a startling and important advance. It comes as a surprise to many in the community—certainly to me—that a phenotype as specific and ethologically relevant as syntactic grooming would be modifiable by a specific alteration in microglia. And yet this is precisely what the new paper shows—and shows with very elegantly designed and performed experiments, which leave little doubt as to the striking conclusion. This study will increase interest in the interaction between immune or inflammatory processes and specific behaviors in a variety of basic and pathological contexts, and this is a salubrious advance in the field.

More vexing is the question of whether or not these mice in general, and the new finding in particular, advance our understanding of...  Read more


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