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Annotation

Siddiqui TJ, Pancaroglu R, Kang Y, Rooyakkers A, Craig AM. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J Neurosci . 2010 Jun 2 ; 30(22):7495-506. PubMed Abstract

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Comment by:  Joris de Wit
Submitted 8 August 2010 Posted 8 August 2010

Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are a small family of neuronal surface proteins. Their role in the nervous system remained fairly obscure until three studies published last year raised interest in these proteins. First, the lab of Ann Marie Craig at the University of British Columbia identified LRRTMs as synapse-promoting molecules in cell culture (Linhoff et al., 2009). Then, two papers from the lab of Thomas Südhof at Stanford University and the lab of Anirvan Ghosh at the University of California, San Diego, showed that LRRTMs mediate their effects on synapse formation through binding to presynaptic neurexins (de Wit et al., 2009; Ko et al., 2009). This finding came as a surprise, since neurexins, which have been implicated in schizophrenia and autism spectrum disorders, were previously known as the binding partners for the post-synaptic adhesion molecule, neuroligin. A new study from the lab of Ann Marie...  Read more


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