Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Kegeles LS, Abi-Dargham A, Frankle WG, Gil R, Cooper TB, Slifstein M, Hwang DR, Huang Y, Haber SN, Laruelle M. Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch Gen Psychiatry . 2010 Mar ; 67(3):231-9. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Oliver D. Howes
Submitted 9 April 2010 Posted 9 April 2010

Challenging the Dopamine Dogma: Do We Need to Ditch the Mesolimbic Focus?
The dogma that hyperactivity in the mesolimbic dopaminergic pathways underlies the psychotic symptoms of schizophrenia continues to feature in psychiatric textbooks—despite the fact that it was largely based on rodent, rather than human, studies. Two recent positron emission tomography (PET) studies have taken advantage of improvements in scanner resolution and new understanding of primate meso-striato-cortical circuits to evaluate this mesolimbic dogma in patients. Last year, we used PET to show that patients with schizophrenia have elevated presynaptic dopamine synthesis capacity in the part of the striatum linked to associative cortical regions (the “associative striatum”) (Howes et al., 2009). Now, in this month’s Archives of General Psychiatry, Lawrence Kegeles and colleagues at Columbia University, New York, write that they used PET to study synaptic dopamine levels in schizophrenia. They report increased levels of synaptic dopamine...  Read more

View all comments by Oliver D. Howes
Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright