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Vuillermot S, Weber L, Feldon J, Meyer U. A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia. J Neurosci . 2010 Jan 27 ; 30(4):1270-87. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Mikhail Pletnikov
Submitted 1 March 2010 Posted 1 March 2010

Vuillermot et al. have published a new study that evaluates the effects of early prenatal immune stimulation with Poly I:C on development of the dopaminergic system and dopamine-related behaviors in juvenile and adult mice. They found that prenatal immune activation at early/middle gestation in mice produced age-dependent dopamine abnormalities. New important findings are the effects of immune activation on the fetal dopamine system, suggesting that adverse environmental factors can affect prenatal development of the dopamine system. This report advances our understanding of the potential targets and mechanisms whereby immune stimulation contributes to adult psychopathology. The report is in good agreement with prior studies of dopamine alterations during postnatal development and adulthood in rats and mice (Zuckerman, 2003; Romero, 2008; Winter et al., 2008).

Another interesting result of the study is that, even though the effects of...  Read more

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