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Pomarol-Clotet E, Canales-Rodríguez EJ, Salvador R, Sarró S, Gomar JJ, Vila F, Ortiz-Gil J, Iturria-Medina Y, Capdevila A, McKenna PJ. Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging. Mol Psychiatry . 2010 Jan 12 ; PubMed Abstract

Comments on Paper and Primary News
Comment by:  Vince Calhoun
Submitted 26 January 2010 Posted 26 January 2010

This is quite interesting work. I feel strongly that more multimodal imaging work is needed in the field to give us a more complete picture of the complex functional and structural changes associated with schizophrenia (and, of course, this kind of work is relevant for other diseases as well). I do notice that the authors imply in the paper that their findings are at odds with our own findings using joint independent component analysis on structural MRI and oddball fMRI data. I would like to point out that since the authors use a working memory task (whereas we used oddball), and they look at convergence based upon separate analyses, whereas we study regions showing a similar co-variation among subjects for both modalities, it is not surprising that the findings would be different. The convergent finding the authors report is quite important, especially given the evidence of significant disease-related changes in the default mode in schizophrenia. Future work is needed to examine this finding in more detail.

View all comments by Vince Calhoun

Comment by:  Samantha BroydSuzannah HelpsEdmund Sonuga-Barke
Submitted 2 February 2010 Posted 2 February 2010

The default-mode network is characterized by spontaneous, low frequency coherence (<0.1 Hz) across the precuneus/posterior cingulate cortex; the medial prefrontal cortex; and the medial, lateral, and inferior parietal cortex (Raichle et al., 2001). Recently, increasing scientific interest has turned to default-mode dysfunction in a number of mental disorders including Alzheimer disease, autism spectrum disorder (ASD), attention-deficit and hyperactivity disorder (ADHD), and schizophrenia (for a review, see Broyd et al., 2009). In this work the authors examine evidence for altered brain structure and function in 32 chronic schizophrenia patients and matched controls by applying three different neuroimaging techniques: voxel-based morphometry (VBM), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). Pomarol-Clotet and colleagues found convergent evidence across all three whole brain voxel-based imaging techniques for altered structure and function of the...  Read more

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