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Ji Y, Yang F, Papaleo F, Wang HX, Gao WJ, Weinberger DR, Lu B. Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc Natl Acad Sci U S A . 2009 Nov 17 ; 106(46):19593-8. PubMed Abstract

Comments on Paper and Primary News
Primary News: Dissecting Dysbindin—Mice, Flies Point to Different Roles

Comment by:  J David Jentsch
Submitted 29 November 2009 Posted 30 November 2009
  I recommend this paper

Over the past few years, specific disruptions in the function of presynaptic, glutamate-releasing terminals in the cortex of animals with genetic insufficiency in dysbindin have been hypothesized and found in mammalian preparations (Talbot et al., 2004; Numakawa et al., 2004; Chen et al., 2008; Jentsch et al., 2009). Setting out to discover genes involved in presynaptic function in Drosophila, Dickman and Davis provide powerful convergent evidence supporting this biological role for the dysbindin protein. The seemingly similar functions for this protein in mammalian cortical synapses and at the invertebrate neuromuscular junction is an exciting finding, though one that should not be interpreted without caution.

Overall, the presynaptic defects that result from loss of dysbindin expression could be the basis of failures of sustained network activity in cortical regions that subserve...  Read more

View all comments by J David Jentsch
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